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一 |     在发表于《Oncotarget》杂志的一项研究中，约翰斯·霍普金斯大学医学院神经外科和肿瘤学教授Gregory Riggins博士和他的团队使用两种不同的小鼠模型来确定抗寄生虫药物甲苯达唑可以减缓或阻止早期和晚期胰腺癌的生长和扩散。“我们认为甲苯咪唑可能在所有阶段都有作用，”Riggins说。“它对早期发现的胰腺癌特别有效。”Riggins和他的团队将甲苯咪唑注射到经过基因工程改造后患上胰腺癌的小鼠身上。    

    Zhou Jiang speaks at an event. Photo: Courtesy of Zhou Jiang
Zhou Jiang, a researcher at the Sichuan Academy of Social Sciences, has a favorite book:  White Deer Tableland or Bai Lu Yuan by renowned writer Chen Zhongshi.
As vice president of the Regional Science Association of China (RSAC), Zhou told the Global Times that a lifetime of reading has profoundly shaped the way he sees and understands the world. It ultimately led him to a career in research and academia, where he teaches and pursues scholarly work.
Since earning his PhD in economics in 2000, he has devoted himself to the study of regional science and economics, a field that demands a constant crossing of disciplinary boundaries, drawing on the fields of geography, sociology, history, and ecology among others.
"Reading has kept alive my sense of curiosity and taught me to ask questions with patience and persistence: Where do disparities in regional development come from? How do policies affect different groups in society? And how can a region pursue both efficiency and equity so that development is not merely effective, but also imbued with a greater sense of humanity and warmth?" Zhou noted. 
Founded in 1991, RSAC is a national academic society dedicated to advancing domestic and international academic exchange and cooperation, providing consulting services on spatial planning, urbanization, and regional development, and offering intellectual support for China's modernization drive.
The 57-year-old researcher noted that reading has empowered him in two distinct ways.
"The first is discernment. When confronted with a complex issue, I try not to settle for a simple conclusion. Instead, I make an effort to understand its broader context, how it has unfolded, and the perspectives of the different people involved," he said. 
"The second is a sense of inner steadiness. Setbacks are an inevitable part of both life and work. Good books remind us that hardship is never ours alone to bear; countless people before us have faced circumstances more difficult than our own, made difficult choices, and found the strength to carry on. Reading cannot solve every problem for us, but it can help us remain calm when challenges arise, giving us the clarity and resilience that allow us not to panic or give up too easily," he said. 
Historical depth

Each time Zhou returns to the White Deer Tableland, he finds something different in its pages. 
"When I first read it as a young person, I was drawn primarily to the characters and the twists and turns of their lives. Later, as I began researching regional economics, I found myself paying closer attention to the changes in the land, the countryside, families and social order presented in the story. Now, approaching 60, I have come to appreciate more deeply the choices the characters make, the constraints they face, and the quiet perseverance they show amid the sweeping currents of their times," he said. 
White Deer Tableland uses Bai Lu village in Northwest China's Shaanxi Province as a microcosm, tracing the feuds and intertwined fortunes of three generations of the Bai (literally meaning white) and Lu families. Through their stories, it captures more than half a century of sweeping historical change, from the final years of the Qing Dynasty (1644-1911) to the 1970s and 1980s. The novel won the Mao Dun Literature Prize, one of China's top literature awards, in 1997.
Zhou prefers literary works with historical depth and a keen eye for social change. 
Regional economics may appear to be concerned with the spatial distribution of industries, population and resources, but at its heart, it is about how people live on a particular piece of land, and why some places flourish while others decline, he noted. 
In this sense, literature and history are more than pastimes beyond professional research. They often help him understand the historical context, cultural traditions and social mentality that lie behind economic data, he said. 
When reading novels, Zhou said that he often pays close attention to the relationship between people and the places they inhabit: How the land shapes the local character, how transportation transforms a region, and how shifts in industry reshape families and villages. Such details may not offer a direct conclusion, but they broaden a researcher's perspective. They also serve as a reminder that research should look beyond growth rates and statistical indicators to consider the sense of fulfillment experienced by ordinary people and the dignity of human beings.
Understanding ourselves
Once, while tidying his study, he came across a book filled with notes he had scribbled in his early years. Among them was a question that particularly caught his attention: "In the face of sweeping changes in the times and profound social transformation, what can a person truly determine for himself?"
Looking at those words he had written in his youth was like coming face to face with the person he had been decades ago.
Reading is not simply the act of understanding a book; it is also a record of a person's own growth, he said. The same book can reveal something entirely different when read at different stages of life. 
When we are young, we turn to books in search of answers; but when we become seasoned, we read more to understand life, to understand others, and ultimately, to better understand ourselves, Zhou said. 
In this era of fragmented information, AI can help people access information quickly, organize materials, and gain a basic understanding of unfamiliar fields. Yet deep reading, Zhou said, allows people to see how a conclusion is reached — what evidence supports it, where its boundaries lie, and what alternative interpretations it may invite.
What truly shapes a person, after all, is not how much information they have browsed, but the words that have made them pause and reflect - and the words that have remained with them for many years, he added. 
。该团队测量了炎症和组织的变化，以及每个肿瘤的阶段、分级和转移状态。甲苯咪唑最初是通过切断寄生虫的营养供应来对抗蛔虫、钩虫和其他寄生虫感染，它能抑制微管蛋白的形成。Riggins解释说，微管蛋白既是细胞内部的微观“骨架”，也是“运输的高速公路”。该药物进入寄生虫的肠道并破坏微管蛋白，使寄生虫饿死。该研究表明，甲苯咪唑可能在胰腺癌中发挥类似的作用，通过塌陷癌细胞的结构，同时还有其他机制，如减少炎症。Riggins说，他希望通过人体临床试验继续他的团队的研究：“我们主张将甲苯咪唑作为一种疗法用于那些在转移前被诊断出来的人，看看我们是否可以减缓或预防胰腺癌，”Riggins说。“对于那些更晚期的癌症患者，它可能是某些手术的替代方案。甲苯咪唑作为初始治疗后的一种疗法可能有实用价值，以防止15%至20%接受手术的胰腺癌患者的肿瘤复发。它还可能增加其余80%至85%的晚期患者对标准化疗反应的持久性。

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